Blar i Bergen Open Research Archive på forfatter "Hughes, Timothy"
-
Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank
O'Connell, Kevin S.; Sønderby, Ida Elken; Frei, Oleksandr; van der Meer, Dennis; Athanasiu, Lavinia; Smeland, Olav Bjerkehagen; Alnæs, Dag; Kaufmann, Tobias; Westlye, Lars Tjelta; Steen, Vidar Martin; Andreassen, Ole Andreas; Hughes, Timothy; Djurovic, Srdjan (Journal article; Peer reviewed, 2021)Background Altered expression of the complement component C4A gene is a known risk factor for schizophrenia. Further, predicted brain C4A expression has also been associated with memory function highlighting that altered ... -
Computational analysis of the evolutionary dynamics of proteins on a genomic scale
Hughes, Timothy (Doctoral thesis, 2007-01-16)Biology is primarily concerned with the study of all phenotypic aspects of living organisms and evolutionary biology is more specifically interested in elucidating how different phenotypes evolved. Proteins (and RNA ... -
Decreased IL-1β-induced CCL20 response in human iPSC-astrocytes in schizophrenia: Potential attenuating effects on recruitment of regulatory T cells
Akkouh, Ibrahim; Ueland, Thor; Hansson, Lars; Inderhaug, Elin; Hughes, Timothy; Steen, Nils Eiel; Aukrust, Pål; Andreassen, Ole Andreas; Szabo, Attila; Djurovic, Srdjan (Journal article; Peer reviewed, 2020)Schizophrenia (SCZ) is a severe mental disorder with a high heritability. Although its pathophysiology is mainly unknown, dysregulated immune activation and inflammation have recently emerged as possible candidates in the ... -
Dose-dependent transcriptional effects of lithium and adverse effect burden in a psychiatric cohort
Krull, Florian; Akkouh, Ibrahim Ahmed; Hughes, Timothy; Bettella, Francesco; Athanasiu, Lavinia; Smeland, Olav Bjerkehagen; O'Connell, Kevin Sean; Brattbakk, Hans-Richard; Steen, Vidar Martin; Steen, Nils Eiel; Djurovic, Srdjan; Andreassen, Ole (Journal article; Peer reviewed, 2022)Lithium is the first-line treatment for bipolar disorder (BD), but there is a large variation in response rate and adverse effects. Although the molecular effects of lithium have been studied extensively, the specific ... -
Elevated expression of a minor isoform of ANK3 is a risk factor for bipolar disorder
Hughes, Timothy; Sønderby, Ida Elken; Polushina, Tatiana; Hansson, Lars Johan Axel; Holmgren, Asbjørn; Athanasiu, Lavinia; Melbø-Jørgensen, Christian; Hassani, Sahar; Hoeffding, Louise K.; Herms, Stefan; Bergen, Sarah E.; Karlsson, Robert; Song, Jie; Rietschel, Marcella; Nöthen, Markus M.; Forstner, Andreas J.; Hoffmann, Per; Hultman, Christina M.; Landén, Mikael; Cichon, Sven; Werge, Thomas; Andreassen, Ole Andreas; Le Hellard, Stephanie; Djurovic, Srdjan (Peer reviewed; Journal article, 2018)Ankyrin-3 (ANK3) is one of the few genes that have been consistently identified as associated with bipolar disorder by multiple genome-wide association studies. However, the exact molecular basis of the association remains ... -
ELM: the status of the 2010 eukaryotic linear motif resource
Gould, Cathryn M.; Diella, Francesca; Via, Allegra; Puntervoll, Pål; Gemünd, Christine; Chabanis-Davidson, Sophie; Michael, Sushama; Sayadi, Ahmed; Bryne, Jan Christian; Chica, Claudia; Seiler, Markus; Davey, Norman E.; Haslam, Neill; Weatheritt, Robert J.; Budd, Aidan; Hughes, Timothy; Pas, Jakub; Rychlewski, Leszek; Trave, Gilles Michel; Aasland, Rein; Helmer-Citterich, Manuela; Linding, Rune; Gibson, Toby J. (Peer reviewed; Journal article, 2009-11-17)Linear motifs are short segments of multidomain proteins that provide regulatory functions independently of protein tertiary structure. Much of intracellular signalling passes through protein modifications at linear motifs. ... -
Exploring lithium's transcriptional mechanisms of action in bipolar disorder: a multi-step study
Akkouh, Ibrahim; Skrede, Silje; Holmgren, Asbjørn; Ersland, Kari Merete; Hansson, Lars Johan Axel; Bahrami, Shahram; Andreassen, Ole Andreas; Steen, Vidar Martin; Djurovic, Srdjan; Hughes, Timothy (Peer reviewed; Journal article, 2019)Lithium has been the first-line treatment for bipolar disorder (BD) for more than six decades. Although the molecular effects of lithium have been studied extensively and gene expression changes are generally believed to ... -
Expression of TCN1 in Blood is Negatively Associated with Verbal Declarative Memory Performance
Akkouh, Ibrahim; Ueland, Torill; Andreassen, Ole Andreas; Brattbakk, Hans-Richard; Steen, Vidar Martin; Hughes, Timothy; Djurovic, Srdjan (Peer reviewed; Journal article, 2018-08-23)Memory is indispensable for normal cognitive functioning, and the ability to store and retrieve information is central to mental health and disease. The molecular mechanisms underlying complex memory functions are largely ... -
A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia
Szabo, Attila; Akkouh, Ibrahim Ahmed; Vandenberghe, Matthieu; Osete, Jordi Requena; Hughes, Timothy; Heine, Vivi M.; Smeland, Olav Bjerkehagen; Glover, Joel Clinton; Andreassen, Ole; Djurovic, Srdjan (Journal article; Peer reviewed, 2021)While neurodevelopmental abnormalities have been associated with schizophrenia (SCZ), the role of astroglia in disease pathophysiology remains poorly understood. In the present study, we used a human induced pluripotent ... -
Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders
Osete, Jordi Requena; Akkouh, Ibrahim; Reis de Assis, Denis; Szabo, Attila; Frei, Evgeniia; Hughes, Timothy; Smeland, Olav Bjerkehagen; Steen, Nils Eiel; Andreassen, Ole Andreas; Djurovic, Srdjan (Journal article; Peer reviewed, 2021)Lithium (Li), valproate (VPA) and lamotrigine (LTG) are commonly used to treat bipolar disorder (BD). While their clinical efficacy is well established, the mechanisms of action at the molecular level are still incompletely ... -
Longitudinal Transcriptomic Analysis of Human Cortical Spheroids Identifies Axonal Dysregulation in the Prenatal Brain as a Mediator of Genetic Risk for Schizophrenia
Akkouh, Ibrahim Ahmed; Ueland, Thor; Szabo, Attila; Hughes, Timothy; Smeland, Olav Bjerkehagen; Andreassen, Ole; Requena Osete, Jordi; Djurovic, Srdjan (Journal article; Peer reviewed, 2024)Background Schizophrenia (SCZ) has a known neurodevelopmental etiology, but limited access to human prenatal brain tissue hampers the investigation of basic disease mechanisms in early brain development. Here, we elucidate ... -
Mapping the expression of an ANK3 isoform associated with bipolar disorder in the human brain
Holmgren, Asbjørn; Hansson, Lars; Bjerkaas-Kjeldal, Kristine; Impellizzeri, Agata Antonia Rita; Gilfillan, Gregor; Djurovic, Srdjan; Hughes, Timothy (Journal article; Peer reviewed, 2022)The gene ankyrin-3 (ANK3) has been consistently associated with bipolar disorder (BD) in several genome-wide association studies (GWAS). The exact molecular mechanisms underlying this genetic association remain unknown. ... -
Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci
Witoelar, Aree; Rongve, Arvid; Almdahl, Ina Selseth; Ulstein, Ingun; Engvig, Andreas; White, Linda Rosemary; Selbæk, Geir; Stordal, Eystein; Andersen, Fredrik; Brækhus, Anne; Saltvedt, Ingvild; Engedal, Knut; Hughes, Timothy; Bergh, Sverre; Bråthen, Geir; Bogdanovic, Nenad; Bettella, Francesco; Wang, Yunpeng; Athanasiu, Lavinia; Bahrami, Shahram; Le Hellard, Stephanie; Giddaluru, Sudheer; Dale, Anders M; Sando, Sigrid Botne; Steinberg, Stacy; Stefansson, Hreinn; Snaedal, Jon; Desikan, Rahul S; Stefansson, Kari; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2018-12-27)A large fraction of genetic risk factors for Alzheimer’s Disease (AD) is still not identified, limiting the understanding of AD pathology and study of therapeutic targets. We conducted a genome-wide association study (GWAS) ... -
Patients with schizophrenia and bipolar disorder display a similar global gene expression signature in whole blood that reflects elevated proportion of immature neutrophil cells with association to lipid changes
Torsvik, Anja; Brattbakk, Hans-Richard; Trentani, Andrea; Holdhus, Rita; Stansberg, Christine; Bartz-Johannessen, Christoffer; Hughes, Timothy; Steen, Nils Eiel; Melle, Ingrid; Djurovic, Srdjan; Andreassen, Ole; Steen, Vidar Martin (Journal article; Peer reviewed, 2023)Schizophrenia (SCZ) and bipolar disorder (BD) share clinical characteristics, genetic susceptibility, and immune alterations. We aimed to identify differential transcriptional patterns in peripheral blood cells of patients ... -
Runaway multi-allelic copy number variation at the α-defensin locus in African and Asian populations
Hughes, Timothy; Hansson, Lars; Akkouh, Ibrahim; Hajdarevic, Riad; Bringsli, Jorunn; Torsvik, Anja; Inderhaug, Elin; Steen, Vidar Martin; Djurovic, Srdjan (Journal article; Peer reviewed, 2020-06-04)Alpha defensins are anti-microbial peptides of the innate immune system. The defensin A1 and A3 genes are located in a repeat array of variable copy number (the DEFA1A3 locus) and encode the human neutrophil peptides 1, 2 ... -
Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids
Osete, Jordi Requena; Akkouh, Ibrahim Ahmed; Levglevskyi, Oleksandr; Vandenberghe, Matthieu; Reis de Assis, Denis; Ueland, Thor; Kondratskaya, Elena; Holen, Børge; Szabo, Attila; Hughes, Timothy; Smeland, Olav Bjerkehagen; Steen, Vidar Martin; Andreassen, Ole; Djurovic, Srdjan (Journal article; Peer reviewed, 2023)Lithium (Li) is recommended for long-term treatment of bipolar disorder (BD). However, its mechanism of action is still poorly understood. Induced pluripotent stem cell (iPSC)-derived brain organoids have emerged as a ... -
Transcriptome analysis reveals disparate expression of inflammation-related miRNAs and their gene targets in iPSC-astrocytes from people with schizophrenia
Akkouh, Ibrahim; Hughes, Timothy; Steen, Vidar Martin; Glover, Joel; Andreassen, Ole Andreas; Djurovic, Srdjan; Szabo, Attila (Journal article; Peer reviewed, 2021)Despite the high heritability of schizophrenia (SCZ), details of its pathophysiology and etiology are still unknown. Recent findings suggest that aberrant inflammatory regulation and microRNAs (miRNAs) are involved. Here ... -
Using iPSC Models to Understand the Role of Estrogen in Neuron–Glia Interactions in Schizophrenia and Bipolar Disorder
de Assis, Denis; Szabo, Attila; Osete, Jordi Requena; Puppo, Francesca; O'Connell, Kevin S.; Akkouh, Ibrahim; Hughes, Timothy; Frei, Evgeniia; Andreassen, Ole Andreas; Djurovic, Srdjan (Journal article; Peer reviewed, 2021)Schizophrenia (SCZ) and bipolar disorder (BIP) are severe mental disorders with a considerable disease burden worldwide due to early age of onset, chronicity, and lack of efficient treatments or prevention strategies. ...